Blar i NTNU Open på forfatter "Karlsen, Tom Rune"

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    • DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development 

      Quiles-Jiménez, Ana M T; Gregersen, Ida; Segers, Filip; Skarpengland, Tonje; Kroustallaki, Pinelopi; Yang, Kuan; Kong, Xiang Yi; Lauritzen, Knut Husø; Olsen, Maria Belland; Karlsen, Tom Rune; Nyman, Tuula Anneli; Sagen, Ellen Lund; Bjerkeli, Vigdis; Suganthan, Rajikala; Nygård, Ståle; Scheffler, Katja; Prins, Jurriën; Van der Veer, Eric; Øgaard, Jonas; Fløisand, Yngvar; Jørgensen, Helle F.; Holven, Kirsten Bjørklund; Biessen, Erik A.L.; Nilsen, Hilde; Dahl, Tuva Børresdatter; Holm, Sverre; Bennett, Martin R.; Aukrust, Pål; Bjørås, Magnar; Halvorsen, Bente (Peer reviewed; Journal article, 2021)
      Background and aims Atherogenesis involves a complex interaction between immune cells and lipids, processes greatly influenced by the vascular smooth muscle cell (VSMC) phenotype. The DNA glycosylase NEIL3 has previously ...

    • NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype 

      Karlsen, Tom Rune; Kong, Xiang Yi; Holm, Sverre; Quiles-Jiménez, Ana M T; Dahl, Tuva Børresdatter; Yang, Kuan; Sagen, Ellen Lund; Skarpengland, Tonje; Øgaard, Jonas; Holm, Kristian; Vestad, Beate; Olsen, Maria Belland; Aukrust, Pål; Bjørås, Magnar; Hov, Johannes Espolin Roksund; Halvorsen, Bente; Gregersen, Ida (Journal article; Peer reviewed, 2021)
      Atherosclerosis and its consequences cause considerable morbidity and mortality world-wide. We have previously shown that expression of the DNA glycosylase NEIL3 is regulated in human atherosclerotic plaques, and that ...

    • NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length 

      Karlsen, Tom Rune; Olsen, Maria Belland; Kong, Xiang Yi; Yang, Kuan; Quiles-Jiménez, Ana M T; Kroustallaki, Pinelopi; Holm, Sverre; Lines, Glenn Terje; Aukrust, Pål; Skarpengland, Tonje; Bjørås, Magnar; Dahl, Tuva Børresdatter; Nilsen, Hilde; Gregersen, Ida; Halvorsen, Bente (Peer reviewed; Journal article, 2022)
      Deficiency of NEIL3, a DNA repair enzyme, has significant impact on mouse physiology, including vascular biology and gut health, processes related to aging. Leukocyte telomere length (LTL) is suggested as a marker of ...